منابع مشابه
Fussy mitochondria fuse in response to stress
When cells become committed to apoptosis, they shatter their mitochondrial networks through the actions of the mitochondrial fission protein DRP1. Massive fragmentation of mitochondria facilitates simultaneous release of cytochrome c from all mitochondria within a cell, thus promoting further progression along the apoptotic pathway. In this issue, Tondera et al (2009) describe a new process wit...
متن کاملRegular paper Response of Acanthamoeba castellanii mitochondria to oxidative stress
The purpose of this study was to examine the effects of oxidative stress caused by hydroperoxide (H2O2) in the presence of iron ions (Fe2+) on mitochondria of the amoeba Acanthamoeba castellanii. We used isolated mitochondria of A. castellanii and exposed them to four levels of H2O2 concentration: 0.5, 5, 15, and 25 mM. We measured basic energetics of mitochondria: oxygen consumption in phospho...
متن کاملResponse of Acanthamoeba castellanii mitochondria to oxidative stress.
The purpose of this study was to examine the effects of oxidative stress caused by hydroperoxide (H(2)O(2)) in the presence of iron ions (Fe(2+)) on mitochondria of the amoeba Acanthamoeba castellanii. We used isolated mitochondria of A. castellanii and exposed them to four levels of H(2)O(2) concentration: 0.5, 5, 15, and 25 mM. We measured basic energetics of mitochondria: oxygen consumption ...
متن کاملHeat-stress response of maize mitochondria.
We have identified maize (Zea mays L. inbred B73) mitochondrial homologs of the Escherichia coli molecular chaperones DnaK (HSP70) and GroEL (cpn60) using two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblots. During heat stress (42 degrees C for 4 h), levels of HSP70 and cpn60 proteins did not change significantly. In contrast, levels of two 22-kD proteins i...
متن کاملMitochondria to nucleus stress signaling
Mitochondrial genetic and metabolic stress causes activation of calcineurin (Cn), NFAT, ATF2, and NFkappaB/Rel factors, which collectively alter the expression of an array of nuclear genes. We demonstrate here that mitochondrial stress-induced activation of NFkappaB/Rel factors involves inactivation of IkappaBbeta through Cn-mediated dephosphorylation. Phosphorylated IkappaBbeta is a substrate ...
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ژورنال
عنوان ژورنال: Lab Animal
سال: 2019
ISSN: 0093-7355,1548-4475
DOI: 10.1038/s41684-019-0431-6